Rarer Cannabinoid Effects
Some Rarer Cannabinoids
These are some of the rarer cannabinoids, there over 100 of them. I have summarized the major benefits and use the link to go an expanded explanation of the cannabinoid.
Potential Benefits of CBG
Anxiety and Depression
Chronic Pain
Inflammatory Bowel Disease (IBD)
Glaucoma
Huntington’s Disease
Breast Cancer
Bacterial Infections
Potential Benefits of CBC (cannabichromene)
it seems to synergistically work with other cannabinoids
Cancer
Pain and Inflammation
Brain Cells In a 2013 mouse study, CBC had a positive effect on neural stem progenitor cells (NSPCs), a cell essential to healthy brain function.
Acne
Depression CBC appears to work in conjunction with both THC and CBD to deliver a trifecta of antidepressant properties.
Potential Benefits of CBD
CBD oil intake is not only linked to therapeutic benefits. Scientific studies have shown that the consistent consumption of CBD oil products provides long-term health benefits, primarily by preventing noncommunicable diseases.
1. CBD oil is beneficial for chronic pain management and Ankylosing Spndylitis https://integrative-energetics.com/cbd-for-ankylosing-spondylitis/
2. It prevents digestive disorders
3. It’s useful for mental health It also helps reduce symptoms linked to cognitive impairments that may arise as you age. Cognitive impairments will affect your brain’s essential functions, like memory retention, concentration, decision-making, and ability to learn new things.
Phytocannabinoids are helpful in the regulation of Dravet syndrome and Lennox-Gastaut syndrome. Some other neurological disorders that cannabidiol regulates include multiple sclerosis, Alzheimer’s, Parkinson’s, schizophrenia, and autism spectrum disorder.
4. CBD oil promotes heart health
5. It relieves chemotherapeutic effects
6. CBD oil aids in drug and alcohol rehabilitation therapy
7. It promotes bone health
8. CBD oil boosts overall brain functioning
Potential Benefits of CBN
What are the potential benefits of CBN (cannabinol)? CBN is a non-intoxicating compound that is best known as the cannabinoid created when THC ages. For that reason, it’s usually present in high amounts in older cannabis. While this might be a turn-off for some, others seek out older cannabis just to enjoy the effects of CBN.
Here are a few of the potential benefits of CBN currently being explored in research. Keep in mind, current research on CBN is limited with very few studies demonstrating its effects in the human body.
Antibacterial
Neuroprotectant
Appetite stimulation
Glaucoma
Anti-inflammatory
Maybe for insomnia…The jury is out but people who have tried CBN do say that is helps with sleep.
THCV
THCV is an appetite suppressant. In contrast to THC, THCV may dull the appetite. This may be good for consumers focused on weight loss, but THCV should be avoided by patients treating appetite loss or anorexia.
THCV may help with diabetes.Research shows promise in THCV’s ability to regulate blood sugar levels and reduce insulin resistance.
THCV may reduce panic attacks. It appears to curb anxiety attacks in PTSD patients without suppressing emotion.
THCV may help with Alzheimer’s. Tremors, motor control, and brain lesions associated with Alzheimer’s disease appear to be improved by THCV, but research is in progress.
THCV stimulates bone growth. Because it promotes the growth of new bone cells, THCV is being looked at for osteoporosis and other bone-related conditions.
CBDV
Much of the research around CBDV has centered around its effect on seizures.
Duchenne muscular dystrophy
One study found that taking 10 milligrams (mg) of CBDV daily significantly reduces seizures in those with Rett syndrome, a neurodevelopmental condition associated with autism spectrum disorder (ASD).
In 2019, researchers found that CBDV may treat symptoms of ulcerative colitis. The study found that CBDV’s anti-inflammatory effects lower intestinal inflammation while balancing gut microbiota. It may also reduce nausea, according to animal studies.
Childhood intractable epilepsy and autism spectrum disorder CBDV has shown anti-epileptic results
CBGV
Neuroprotective properties of cannabinoids
This is a chart of the rarer cannabinoids and their effects.
CBGV
CBGV
Research on the therapeutic applications of CBGV is very limited. However, its therapeutic potential is suggested for certain conditions, including some types of cancer and inflammatory processes. It is further postulated that CBGV may enhance the effectiveness of other cannabinoids.
CBGV is seen as a stimulant for other cannabis cannabinoids to help them interact more efficiently with different receptors.
Cancer
CBGV appears to be an antagonist of certain receptors related to the malignancy of some cancer cells, the TRPV2 receptors. These receptors are overexpressed in tumor cells and play a crucial role in cancer proliferation and invasion (3). Although this still needs to be explored in detail, by antagonizing these receptors, CBGV could offer benefits in the treatment of cancers such as prostate and breast cancer.
In studies with tumor cells, CBGV has been shown to reduce proinflammatory cytokines (4) and decrease colorectal cancer cell proliferation (5), indicating the need for further research to fully understand its therapeutic potential.
Cannabinoids are a novel cosmetic agent with very beneficial properties for dry skin.
Dry skin
CBGV shows promise for the treatment of dry skin. One study suggests that it can stimulate the sebaceous glands to induce skin lipid synthesis, which would be beneficial in treating conditions such as dry skin syndrome, xerosis (excessive dryness of the skin), and mitigating the effects of natural aging on the skin (6).
Possible Therapeutic Effects of CBGV
Looking at the way CBGV works in the body, we can say it might actually enhance the effects of other cannabinoids. There are some schools of thought that believe CBGV enhances the benefits of medical marijuana, too.
Here are some different areas that CBGV may help people, therapeutically.
Skin Disease
While other cannabinoids are known for their anti-inflammatory benefits, CBGV according to a procedure carried out through non-psychotropic medication is said to be able to treat acne.
Eye Diseases
CBG is known for its effects in draining aqueous fluid in the eye. Used in combination with CBGV helps in relieving painful intraocular pressure. This is made possible because of the anti-inflammatory and antibacterial methods of action that CBGV and CBG share.
Cancer Mitigation
A study carried out at the University of St. George’s London on the use of non-psychoactive for the treatment of cancer. It was reported that the combination of CBG and CBGV showed shrinkage in cancerous cells and prevented the development of metastases. CBGV caused a halt in all phases of the cell cycle.
CBDV
The Potential Medical Benefits of CBDV
Much of the research around CBDV has centered around its effect on seizures. GW Pharmaceuticals, which developed the first FDA-approved CBD drug called Epidiolex, is actively developing a CBDV-based drug known as GPW42006 to reduce or prevent epileptic and other forms of seizures.
Their research has shown that CBDV affects the neurochemical pathway of the capsaicin receptors involved in both the onset as well as the progression of several types of epilepsy. GW reports that CBDV has shown anti-epileptic results “across a range of in vitro and in vivo models of epilepsy.”
CBDV is also showing promise in several other areas of medicine:
- According to a 2018 rodent study, CBDV has shown promise in helping the neurobehavioral issues associated with Rett syndrome. Rett syndrome is caused by an X chromosome mutation that affects girls with seizures, speech issues, and muscle spasticity. Interestingly, CBDV seems to help with both the genetically determined and chemically-induced forms of this and similar diseases.
- In an animal study published in 2019 in the Journal of Psychopharmacology, CBDV was found to rescue memory defects in mice that have the same genetic defect as people with Rett syndrome. CBDV also helped with neurological defects, but the effects were transient.
- In a similar 2019 study published in the British Journal of Pharmacology, CBDV was found to possibly benefit patients with Duchenne muscular dystrophy (DMD). This disease is characterized by chronic inflammation and irreversible skeletal muscle damage and degeneration. CBDV may reduce inflammation and restore and even enhance muscle function. CBDV also improved locomotion, highlighting the compound’s potential as a novel therapy for DMD.
- Childhood intractable epilepsy and autism spectrum disorder (ASD) often go hand in hand. CBDV is being investigated as a potential treatment of some of the more significant ASD issues, such as repetitive behavioral problems, cognitive challenges, and communication and social functioning issues.
- CBDV may also be a powerful anti-nausea agent. Initial research on rodents shows that CBDV likely acts as an agonist to the CB1 receptors, thereby blocking the nausea response.
Although CBDV was discovered 50 years ago, research is just commencing in an appreciable way. With GW Pharmaceuticals and their CBDV clinical trials underway, this is a hopeful beginning in unlocking the secrets of another potentially powerful cannabinoid.
What is CBN (cannabinol)
What is CBN (cannabinol) and what are the benefits of this cannabinoid?
Emily EarlenbaughLast updated April 14, 2025
If you use cannabis, you’ve probably heard all about it’s two most popular cannabinoids, THC and CBD. But these aren’t the only cannabinoids produced by the plant. You’ll also find minor cannabinoids, like CBN (cannabinol), among others.
These medicinal compounds, unique to cannabis alone, can be very different from each other in terms of their effects and medicinal benefits. So, if you want to know how your cannabis will affect you, learning about the different cannabinoids is the first step.
So, let’s get to know CBN a little better.
What are the potential benefits of CBN (cannabinol)?
CBN is a non-intoxicating compound that is best known as the cannabinoid created when THC ages. For that reason, it’s usually present in high amounts in older cannabis. While this might be a turn-off for some, others seek out older cannabis just to enjoy the effects of CBN.
Here are a few of the potential benefits of CBN currently being explored in research. Keep in mind, current research on CBN is limited with very few studies demonstrating its effects in the human body.
Antibacterial
Studies on CBN have found that it may be a potent antibacterial agent. In lab settings, CBN was tested on strains of MRSA bacteria that are resistant to traditional antibiotics. Researchers found it to be a potent antibacterial agent against these resistant strains. Perhaps in the future, we will see CBN being used to fight off bacterial infections that our usual antibiotics can’t heal.
Neuroprotectant
CBN may also be a powerful neuroprotectant. In one rodent study, researchers used CBN as a treatment for ALS and found that it was able to delay the onset of the condition. While human studies need to be done, this suggests that CBN may provide a powerful tool in the fight against ALS and other neurodegenerative conditions.
Appetite stimulation
In rodent studies, CBN increased the amount of food that rat subjects ate, suggesting that it could be an effective appetite stimulant. Since some avoid THC (another well-known appetite stimulant) due to its intoxicating effects, CBN could potentially offer an alternative for those seeking the munchies without the high—but more research is needed.
Glaucoma
CBN may also be helpful for those suffering from glaucoma. One study on rabbits found that CBN (as well as THC) reduces intraocular pressure—the biggest risk factor for glaucoma. Still, research is in early stages and CBN hasn’t been shown to be superior to other glaucoma medications. More research is needed to know if cannabinoids could ever effectively replace any traditional treatments for glaucoma.
Anti-inflammatory
CBN may also be a potent anti-inflammatory agent capable of helping those with rheumatoid arthritis. In one rodent study, CBN was shown to reduce arthritis. While more research needs to be done, this could end up being an incredible help to those suffering from this debilitating condition.
Popular misconceptions about CBN
If you’ve read about CBN before, you may be surprised that you didn’t see “insomnia” on the list of medical benefits above. CBN is often praised as a super-sedative, but reputations can be deceiving.
Although there hasn’t been much research on CBN’s sedating effects (or lack thereof), one human study did look at this question back in the 1970s. While the study was small, none of the respondents reported that CBN made them feel sleepy.
So why does everyone say that it’s sedating?
Well there are two possible reasons, and they both lead back to one source: People noticed that older cannabis (which is high in CBN) makes them sleepy and assumed it must be the CBN.
First, it may be that the combination of CBN and THC is what actually causes the sedative effect.
In the same study that found CBN didn’t make subjects sleepy, researchers tested CBN alone, CBN with THC, and THC alone. While THC produced some drowsiness on its own, the combination of the two produced even higher levels of drowsiness. So perhaps those enjoying high CBN cannabis, which also contains THC, have noticed the synergistic effects and assumed the sedative effect was attributable to the CBN alone.
In other words, the older cannabis that is high in CBN is also high in sedating terpenes. These terpenes, rather than the CBN, could account for the sedative effects.
But even without the THC connection, there may be other factors which cause higher CBN cannabis to be sedating.
“Pure CBN is not particularly sedating,” explains leading cannabis researcher and neurologist Dr. Ethan Russo, “But it is typically found in aged cannabis in which the monoterpenoids have evaporated leaving the more sedating oxygenated sesquiterpenoids. This accounts for the discrepancy.”
In other words, the older cannabis that is high in CBN is also high in sedating terpenes (other active chemicals in the plant). These terpenes, rather than the CBN, could account for the sedative effects.
While CBN may not be sedating on its own, you may be able to take advantage of its synergistic effects with THC to get the sleep inducing effects you are looking for.
Another misconception about CBN is that high CBN products will always be non-intoxicating. While CBN alone is non-intoxicating, it can actually increase euphoric effects of THC. If you are looking to take advantage of CBN’s benefits without a high, make sure you are using products that don’t contain much THC.
Health benefits of CBD oil
CBD oil intake is not only linked to therapeutic benefits. Scientific studies have shown that the consistent consumption of CBD oil products provides long-term health benefits, primarily by preventing noncommunicable diseases.
1. CBD oil is beneficial for chronic pain management
CBD oil has been used as a pain reliever since ancient times. It’s been proven to be a better and safer option than opioids. Opioids have a lower safety profile since it’s easier for patients to deviate from the recommended dosage.
Opioid dependence continues to be a problem in the medical field, but potent pain relievers like CBD oil significantly contribute to the fight against drug dependence. This is largely thanks to its lack of psychoactive properties.
CBD for Ankylosing Spondylitis
2. It prevents digestive disorders
Cannabidiol boosts your digestive system to prevent disorders like irritable bowel diseases. Stomach-related conditions can cause discomfort or pain, diarrhea, nausea, vomiting, constipation, and bloating, among other symptoms.
Cannabidiol aids in relieving stomach-related disorders. Besides assisting in digestive therapy, it promotes a healthy gut system by maintaining proper conditions for gut bacteria to flourish. A healthy gut system generally boosts your overall health.
3. It’s useful for mental health
Clinical trials have confirmed that CBD oil produces a soothing effect that reduces psychotic symptoms. It controls psychotic symptoms like confusion, speech deficiencies, and sudden loss of interest in activities that used to matter to the person.
It also helps reduce symptoms linked to cognitive impairments that may arise as you age. Cognitive impairments will affect your brain’s essential functions, like memory retention, concentration, decision-making, and ability to learn new things.
Phytocannabinoids are helpful in the regulation of Dravet syndrome and Lennox-Gastaut syndrome. Some other neurological disorders that cannabidiol regulates include multiple sclerosis, Alzheimer’s, Parkinson’s, schizophrenia, and autism spectrum disorder.
More research is needed on CBD oil’s effects on post-traumatic stress disorder, lack of sleep (insomnia), Tourette syndrome, and bipolar disorder.
4. CBD oil promotes heart health
It has antioxidants that reduce oxidative stress and inflammation, lowering blood pressure. Oxidative stress is a significant contributor to heart diseases. Heart-related complications may include diabetes, kidney, and liver damage.
5. It relieves chemotherapeutic effects
Chemotherapy is one of the main forms of cancer treatment. Patients typically receive chemotherapy drugs in large doses, and like many drugs, they also have side effects.
Chemotherapy-related side effects tend to be severe and include pain, nausea, vomiting, and loss of appetite. CBD oil aids in reducing cancer-related symptoms too. Although helpful, CBD oil is not a one-size-fits-all solution for all types of cancer.
6. CBD oil aids in drug and alcohol rehabilitation therapy
It significantly aids the rehabilitation process by reducing drug withdrawal symptoms like cravings. Research has notably found it to reduce alcohol, tobacco, heron, and other stimulant cravings.
7. It promotes bone health
Studies have found that cannabidiol enhances bone regeneration in fractured rats. Due to age, genetics, and other factors, improved bone regeneration processes are essential to replace lost bone mass over time. CBD oil also aids in preventing rheumatoid arthritis.
8. CBD oil boosts overall brain functioning
Phytocannabinoids regulate stress, anxiety, and other factors affecting proper brain development and functioning. Its bioactive compounds also enhance memory retention and other cognitive abilities.
CBD oil intake may result in side effects like diarrhea, fatigue, weight loss, and appetite changes. An allergic reaction or improper dosage can bring about these symptoms. Talk to your doctor to get a prescription or figure out if CBD oil is right for you. Keep in mind that self-medicating may result in more problems than solutions.
CBD for ankylosing spondylitis
CBD for ankylosing spondylitis
As an alternative treatment for the chronic pain of ankylosing spondylitis, CBD is a good choice. Studies reported in the Journal of Experimental Medicine showed that CBD reduced chronic pain and inflammation in some subjects.
CBD is a potent anti-inflammatory that inhibits cell proliferation, which basically means the cell production and division that are responsible for the excessive build-up of bone tissue in the vertebrae.
CBD also suppresses cytokine production, responsible for between cells for immune response. Cytokines stimulate responses towards the inflamed sites.
Cannabidiol also induces T-regulatory cell production to combat the adverse effects of an overactive immune system.
Because AS is an autoimmune disease, it begins at a cellular level, and that is where CBD is at its most helpful. In simple terms, CBD calms the immune response and helps to lessen pain and inflammation.
The human body’s endocannabinoid system (ECS) regulates pain and the body’s immune response, among its other functions. Made up of receptors in the central nervous system (CB1) and the immune system (CB2), the ECS promotes and facilitates the production and delivery of the body’s neurotransmitters. The ECS’ role in healing inflamed tissue correlates clinically with preventing and treating inflammation-induced pain.
The National Institutes of Health sponsored an investigation into CBD’s role in reducing chronic pain and inflammation. The research has shown that CBD’s anti-oxidative and anti-inflammatory properties were instrumental in reducing chronic pain. CBD acts on your body’s CB1 receptors to mute the pain signal to the brain through the cellular mechanisms outlined above.
Frontiers in Pharmacology reviewed studies done between 1975 and 2018 into the effects of CBD on pain. In the studies, researchers investigated pain as a symptom of arthritis. The 2018 review concluded that CBD is an effective treatment for pain, with few side effects.
Cannabidiol agonist activity (initiation of a physiological response, combined with a receptor) at CB2 receptors appears to be responsible for its anti-inflammatory properties and its influence on pain perception. Initial human and animal studies support the premise that CBD reduces chronic pain and inflammation.
CBD has another role in improving pain and inflammation related to AS, and that is in improving sleep quality. Poor sleep may be a result of pain, which in turn impacts pain management. Proper rest improves not only pain management efficacy but also mood that can play a part in improving perceived pain.
Many drugs used to treat chronic pain carry a significant risk, not only of addiction but also of breathing-related sleep disorders. Opioids are the most common culprits, especially when combined with central nervous system depressants. CBD, on the other hand, is non-addictive and has few side effects, but as always, consult the doctor before beginning a CBD regimen.
How to use CBD for AS
CBD comes in many forms, but the most common ways to take it are orally or topically. Capsules or tinctures are the most common oral forms. It may take as long as 2 hours for CBD capsules to begin working, depending on stomach contents and digestive health.
Sublingual sprays or tinctures offer better absorption, going directly into the bloodstream. Users hold the liquid under the tongue for 1 – 2 minutes. The CBD should take effect in about an hour.
Usually, it takes time and experimentation to find an effective dose. Most new users begin with two 5 mg doses, taken morning and evening. Every 7 – 10 days, increase each dose by about half until pain relief is effective.
CBD topicals come as lotions, ointments, creams, and balms and are applied directly to the skin where pain relief is desired. Ointments, salves, and balms tend to require fewer applications than lotions and creams. Some early research has shown that topical applications can have better absorption rates than oral rates. Apply generously and frequently for pain relief.
Whether taken orally or used topically, find a provider that can show a third-party testing analysis. The analysis will show the purity and ingredients. The certificate of analysis should also show how much CBD is delivered per dose. The goal is CBD purity of greater than 98%. The remaining ingredients should be other cannabinoids, terpenes, and flavonoids, as well as the carrying agent.
The science into CBD and its potential for conditions such as ankylosing spondylitis is in the very early stages. Preliminary studies, trials, and user reports show that CBD holds great promise for the relief of chronic pain.
What Is CBC and What Are the Benefits
What Is CBC and What Are the Benefits of This Cannabinoid?
Jacqueline HavelkaLast updated July 31, 2025
By now you’re probably familiar with cannabinoids, especially the most common ones, THC and CBD. But you likely haven’t heard of cannabichromene, also known as CBC. Discovered over 50 years ago, CBC is considered one of the “big six” cannabinoids prominent in medical research. It doesn’t get as much attention, but CBC’s benefits are extremely promising.
CBC has the same origins as both THC and CBD do in that they all stem from cannabigerolic acid (CBGA). Cannabis plants produce CBGA, the precursor to three major cannabinoids: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA).
A list of major cannabinoids in cannabis and their effects
The specific plant enzymes cascade and “direct” the breakdown product into one of the three lines. For CBC, it converts from CBGA into cannabichrome carboxylic acid (CBCA), and then finally to CBC after exposure to heat or ultraviolet light.
CBC Works With Other Cannabinoids
CBC is non-intoxicating, so it doesn’t produce a euphoric high like THC. The reason it is non-intoxicating is because it binds poorly to CB1 cannabinoid receptors in the brain. But CBC does bind with other receptors in the body, such as the vanilloid receptor 1 (TRPV1) and transient receptor potential ankyrin 1 (TRPA1), both of which are linked to pain perception. When CBC activates these receptors, increased levels of the body’s natural endocannabinoids like anandamide are released.
While CBC definitely has singular benefits, researchers also think that it seems to synergistically work with other cannabinoids, a term known as the entourage effect. This effect of THC and CBD working together is well-known, but whether other cannabinoids have entourage effects is not well understood.
CBC’s Medicinal Potential
The purported benefits of CBC have far-reaching implications. Below are a few medical conditions that may be alleviated by cannabichromene.
Cancer
Cannabichromene may be a powerful cancer fighter, and the reason might be its interaction with the body’s natural endocannabinoid, anandamide. CBC also appears to inhibit the uptake of anandamide, allowing it to remain longer in the bloodstream.
A recent study in which tumor growth was initiated in mice (two-stage mouse skin carcinogenesis model) showed cannabinoids might be effective in inhibiting both inflammation and tumor growth. Since anandamide has been shown to fight breast cancer in vitro and in vivo, this shows promise that CBC and other cannabinoids might one day be a chemopreventive agent.
CBC as a potential cancer fighter was first published in a 2006 study that looked at cannabinoids other than THC and their possible effects on cancer. While THC is known for its anti-tumor properties for several different forms of cancer, its powerful psychotropic qualities can make it difficult for chemotherapy use. So far, research has found CBC to be the second-most-potent cannabinoid at inhibiting the growth of new cancer cells (CBG was the most potent).
Pain and Inflammation
Cannabichromene has been shown to block pain and inflammation associated with collagen-induced osteoarthritis. Cannabinoids like CBC act on inflammation differently than non-steroidal anti-inflammatory drugs (NSAIDs) do, and don’t have the side effects of these medications. In another example of the entourage effect, CBC in combination with THC had significant anti-inflammatory response in a recent animal study; together, the two cannabinoids produced a much greater effect on inflammation than by themselves.
Brain Cells
In a 2013 mouse study, CBC had a positive effect on neural stem progenitor cells (NSPCs), a cell essential to healthy brain function. NSPCs became more viable when in the presence of CBC, and that shows promise because NSPCs differentiate into astroglial cells, the most important cells for maintaining brain homeostasis. The astroglial cells perform a whole host of functions, including neurotransmitter direction and defending against oxidative stress. Astroglia counteract many of these issues—oxidative stress, inflammation, toxicity—that create neurological diseases and brain pathologies like Alzheimer’s disease.
Acne
A research team that had previously shown CBD’s effect on acne studied other cannabinoids, including CBC, for the same effects. Indeed, CBC was shown to be a powerful inhibitor of acne. As a skin disease, acne is characterized by excess sebum production and sebaceous gland inflammation. It turns out that CBC exhibited powerful anti-inflammatory properties and also suppressed excessive lipid production in the sebaceous glands. CBC also reduced levels of arachidonic acid (AA), which is needed to create the lipogenesis. More research is needed, but CBC might just one day become a very powerful anti-acne treatment.
Depression
In another amazing display of the entourage effect, CBC appears to work in conjunction with both THC and CBD to deliver a trifecta of antidepressant properties.
The therapeutic promise of CBC is important and requires more research to determine its power by itself as well as with other cannabinoids working together for an entourage effect. Cannabis patients today are limited in the products available to them, but hopefully as new studies emerge and cannabis laws loosen, new medicines with a diversity of cannabinoids will soon become an option.
Potential Benefits of CBG
Potential Benefits of CBG
Research shows that CBG may have therapeutic effects. While more research is needed to learn the exact effects of this cannabinoid and its potential benefits, here are a few of their findings.
Anxiety and Depression
One small-scale study found that the number one reason people used cannabis preparations high in CBG was to reduce anxiety, with one in three using it to ease depression.4 Most of the users reported that they felt that CBG was more effective for these purposes than conventional medicines.
Chronic Pain
In the study mentioned above, the second-most common reason people used CBG was for chronic pain, with 73.9% reporting that it worked better than traditional medicines.4 Chronic pain is pain that lasts three months or more. This type of condition impacts roughly one in five U.S. adults or around 51.6 million Americans.5
Centers for Disease Control and Prevention. Chronic pain among adults — United States, 2019-2021.
Inflammatory Bowel Disease (IBD)
According to one review, between 15% and 40% of people with inflammatory bowel disease (IBD) use cannabis and cannabinoids to increase their appetite as well as to reduce their pain.6 Although studies have found promise for its effects on IBD, researchers added that high-quality evidence is lacking, as is advice as to the proper dose and mode of administration.
Glaucoma
Individuals with high eye pressure, also known as intraocular pressure (IOP), are at a greater risk of developing glaucoma.7 Several studies have looked at the impact of cannabinoids on IOP. Many have found that these cannabis derivatives help lower IOP in both humans and animals, making them a potential glaucoma treatment.8
Huntington’s Disease
Huntington’s disease causes a breakdown of nerve cells in the brain. Cannabigerol appears to have a positive effect on cell viability while also protecting certain cells (N2a cells) from the toxic effects of excitatory neurotransmitters that, when activated too long, lead to cell death.9
Cancer
A 2021 meta-analysis reports that CBG appears to not only stop breast cancer cells from increasing in numbers but may also kill off inflammatory cells associated with this cancer type.10
Bacterial Infections
A 2020 study on the antibiotic potential of cannabis found that CBG has antibacterial properties, especially against methicillin-resistant strains of Staphylococcus aureus.11 Staphylococcus aureus is also known as MRSA, a drug-resistant bacteria that causes staph infections.
Neuroprotective properties of cannabinoids in multiple system atrophy (and other neurological diseases)
Neuroprotective properties of cannabinoids in multiple system atrophy
This is the search:
https://duckduckgo.com/?q=Neuroprotective+properties+of+cannabinoids+in+multiple+system+atrophy&t=ffab&ia=web
https://pmc.ncbi.nlm.nih.gov › articles › PMC9640911
Cannabidiol for neurodegenerative disorders: A comprehensive review
Cannabidiol (CBD), the major non-psychoactive component of cannabis, has recently emerged as a potential prototype for neuroprotective drug development due to its antioxidant and anti-inflammatory properties and its well-tolerated pharmacological behavior.
https://www.explorationpub.com › Journals › ent › Article › 100498
Multilayered neuroprotection by cannabinoids in neurodegenerative diseases
In this context, the endocannabinoid system and exogenous cannabinoids represent an interesting field of research due to numerous studies highlighting the neuroprotective effect of cannabinoids from different sources, i.e., endogenous, phytocannabinoids, and synthetic cannabinoids.
https://www.mdpi.com › 2218-273X › 16 › 2 › 225
Cannabinoids, the Blood-Brain Barrier, and Neurodegeneration … – MDPI
Feb 2, 2026The various neuroprotective properties of cannabinoids through many cellular and molecular pathways in neurodegenerative diseases have been demonstrated. CBD and THC have been researched much more extensively than many other phytocannabinoids.
(PDF) The Neurotherapeutic Arsenal in Cannabis sativa … – ResearchGate
Cannabinoids, pivotal in cannabis’s bioactivity, exhibit well-documented analgesic, anti-inflammatory, and neuroprotective effects.
https://link.springer.com › content › pdf › 10.1007 › s12035-026-05780-5.pdf
Neuroprotective Role of Cannabinoid CB – Springer
Abstract Multiple sclerosis (MS) is a chronic neuroinflammatory disorder characterized by demyelination, oligodendrocyte (OLG) loss, and progressive neurological decline. While current disease-modifying therapies primarily target immune responses, they offer limited neuroprotective or remyelinating effects. Through its receptors, including cannabinoid receptor type 1 (CB1R) and the G protein …
https://www.sciencedirect.com › science › article › pii › S1568163724002046
Cannabidiol and neurodegeneration: From molecular mechanisms to …
Sep 1, 2024Cannabidiol (CBD) is a non-psychotic natural cannabinoid obtained from Cannabis sativa that possesses multiple pharmacological actions, including antioxidant, anti-inflammatory, and neuroprotective effects in various NDs and other neurological disorders both in vitro and in vivo.
https://www.nature.com › articles › s41582-019-0284-z
Cannabinoids and the expanded endocannabinoid system in … – Nature
Garcia-Arencibia, M. et al. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease: importance of antioxidant and cannabinoid receptor-independent properties.
https://www.oatext.com › neuroprotection-by-cannabinoids-in-neurodegenerative-diseases.php
Neuroprotection by Cannabinoids in Neurodegenerative Diseases
Abstract The cannabinoids are found to have particular application as neuroprotectants for mental and motor dysfuction in neurodegenerative diseases. The neuroprotective properties of cannabinoids suggest their therapeutic use for limiting neurological damage. The cannabinoids treatments should not only aim to alleviate specific symptoms but also attempt to delay/arrest disease progression and …
Medicinal Cannabis and Central Nervous System Disorders
Abstract Cannabinoids, including those found in cannabis, have shown promise as potential therapeutics for numerous health issues, including pathological pain and diseases that produce an impact on neurological processing and function. Thus, cannabis use for medicinal purposes has become accepted by a growing majority.
https://onlinelibrary.wiley.com › doi › full › 10.1155 › 2023 › 8825358
Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological …
Its anti-inflammatory, neuroprotective, and anxiolytic properties make it an intriguing compound for further research and development. As our understanding of CBD and its effects on the brain continues to grow, it has the potential to become a valuable tool in the management of neurological conditions [35].
Healthline
https://www.healthline.com › nutrition › cbd-oil-benefits
6 CBD Benefits and Uses (Plus Side Effects) – Healthline
1 day agoCannabidiol, or CBD, is a chemical compound in cannabis with a variety of uses. Here are six benefits of CBD oil.
https://pmc.ncbi.nlm.nih.gov › articles › PMC5938896
ResearchGate
Effects of self-administered cannabidiol in a patient with multiple …
Without any disease-modifying treatment strategy for multiple system atrophy (MSA), the therapeutic management of MSA patients focuses on a multidisciplinary strategy of symptom control.
ScienceDirect https://www.sciencedirect.com › science › article › pii › S1521661611000593
Neuroprotective agents: Cannabinoids – ScienceDirect
In multiple sclerosis, several reports have documented the disturbance of the endocannabinoid system. Considering the actions demonstrated experimentally, cannabinoids might be promising agents to target the main aspects of the human disease.
https://pmc.ncbi.nlm.nih.gov › articles › PMC10586905
Cannabinoids and endocannabinoids as therapeutics for nervous system …
Cannabinoids are lipophilic substances derived from Cannabis sativa that can exert a variety of effects in the human body. They have been studied in cellular and animal models as well as in human clinical trials for their therapeutic benefits in several human diseases. Some of these include central nervous system (CNS) diseases and dysfunctions such as forms of epilepsy, multiple sclerosis …
ScienceDirect
https://www.sciencedirect.com › science › article › pii › S2095496423000249
Neuroprotective potential of cannabidiol: Molecular mechanisms and …
It is believed that CBD has a number of functions in the central nervous system that may be important in the pharmacotherapy of the nonmotor consequences of PD, including anxiety-relieving properties, antipsychotic properties, antidepressant properties and sleep-inducing properties [75].
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles › PMC10526757
Cannabinoids in Medicine: A Multifaceted Exploration of Types …
Moreover, cannabinoids possess neuroprotective properties that could be crucial in treating AD. For instance, they can diminish tau phosphorylation and mitigate the negative impact of beta-amyloid-induced oxidative stress while promoting neurotrophin expression and neurogenesis.
https://www.mdpi.com › 1420-3049 › 29 › 2 › 410
The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti …
The emergence of CBD as a non-psychoactive cannabinoid with purported anti-inflammatory, analgesic, and neuroprotective properties fuelled a significant boom in both research and commercial interest, contributing to the burgeoning market for CBD products [5].
https://pmc.ncbi.nlm.nih.gov › articles › PMC3579248
National Center for Biotechnology Information
https://pmc.ncbi.nlm.nih.gov › articles › PMC9710321
National Center for Biotechnology Information
https://www.explorationpub.com › Journals › ent › Article › 100487
Phytocannabinoids—Evaluation of their therapeutic role in neuroinflammation
Aug 22, 2024It regulates multiple systems in the body including inflammation and endocannabinoid system dysregulation is involved in numerous inflammatory conditions. The Cannabis sativa plant produces over 100 phytocannabinoids, some of which interact with the endocannabinoid system.
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles › PMC11204381
Cannabinoids’ Role in Modulating Central and Peripheral Immunity in …
Jun 10, 2024Cannabinoids (the endocannabinoids, the synthetic cannabinoids, and the phytocannabinoids) are well known for their various pharmacological properties, including neuroprotective and anti-inflammatory features, which are fundamentally important.